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This is a quick one, but it's a common mistake and needs to be nailed.
Anguish affects you. An arrow in the eye affects you. The word 'affect' relates to what influence something has on you. Affective disorders are illnesses that influence your mood.
By contrast, many nasty illnesses are effective (ie they kill you fast). The word effect goes with 'cause and effect' – an effect is an outcome.
It's easy to see why confusion arises, because anguish that affects me may have an effect on you. So good luck...
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